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Alcohol and drugs became a part of social interactions

Caffeine and nicotine have specific pharmacological interactions that make their combined use neurologically more rewarding than either substance alone and that create specific challenges for smokers trying to quit

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Around the world, governments and advocates are now exploring bold endgame approaches: phasing out commercial cigarette sales, creating nicotine-free generations, drastically reducing nicotine content to non-addictive levels, limiting retail availability, and preventing future generations from becoming addicted in the first place

2020;29(Suppl 3):s1639